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Hair Science Institute Researches the embryonic development of human follicular units


Hair problems such as alopecia often have a significant social and psychological influence on patients. This also applies to individuals who have lost their hair as a result of severe burns. Proper wound healing is facilitated by hair follicles and scar formation is prevented. Research conducted on hair follicles or follicle units is useful for many patients who suffer from alopecia problems.

The application of research to capillary growth

There are intensive studies being conducted on hair growth and the disorders that affect it. The study of follicular units has not been finished yet. Human fetal material research is frequently restricted. As a result, the results, studies, diseases and healing of injuries very often depend on animal studies.

Those studies cost a tremendous amount of money and time. Even though animal experience has yielded valuable and valuable information, it is still acknowledged that there are differences between animal and human skin. It is thus necessary to achieve meaningful results on human models. Future therapy aimed at healing these problems could require the models used for human diseases. For this research, we can use three-dimensional structures made up of hair and hair stem cells from the patient. The knowledge of the genesis of the hair, in other words of its development, is absolutely essential.

Studying the mechanisms that lead to the formation of follicular units

Discovering and decoding the mechanisms that underlie the formation of follicular units within human fetal skin is crucial. Discover the process by which progenitor cells are formed and the subsequent formation of hair within the follicular unit. Laboratory cell studies have demonstrated that all of these organs can be arranged in models that resemble embryos and utilize morphogenesis, proteins, and extracellular matrix.

Knowledge of cell proteins in the skin of human foetuses is essential for understanding epithelial tissues, including skin appendages. The goal is to provide an overview of our current understanding of cell mutations which occur during the development of human skin and follicular unit.

The research carried out by HASCI focused on the genetic knowledge of follicular units

Hasci assessed the potential of this molecular growth process to apply this knowledge to create an in vitro model of humans using human skin that contains hair follicles. The second trimester of gestation is when the human hair follicle develops during embryogenesis. The interaction in this process is influenced by a variety of biochemical forms. The process makes it possible to differentiate the various components of the follicle unit.

HASCI has conducted studies on embryos of both humans and animals

Despite the progress made, the use of cell therapies for hair loss has not advanced. The reason for this is probably a lack of understanding about the ergonomic mechanisms of human organogenesis. In vitro research on the neurogenesis of the follicular unit in vitro is hindered by the lack of adequate studies on the human embryo.

The biomolecular aspects of follicular unit organogenesis have been the primary focus of most studies on follicular unit organogenesis, not the neurogenesis of the follicular unit in vitro. The description of the cellular and molecular morphological stages of the human fetus will not be sufficient. It’s important to pay attention to the impact of the extracellular matrix on the growth of the follicular unit. Research on other species is necessary because human data is scarce.

The Hair Science Institute: at the forefront of this research

The current knowledge on the development of the follicular unit in the human fetus can be completed with techniques reproducing molecular cell production in the Neurogenesis of the Follicular Unit in vivo. on the reproduction of follicular units via in vivo cloning and the hair stem cell transplantation capillary restoration technique, Hasci based his research, Hair Stemcel transplantation, HST is the embodiment of this research.

Hasci studied the evolution in the human fetus of follicular unit genesis

During the creation of follicular units in the fetus during organogenesis of follicular units, epithelial cells interact with surrounding dermal cells. The latter proliferate and form a condensate.
With the formation of the pre-dermal condensate begins the next phase of formation of the follicular unit in organogenesis. As condensate formation progresses, the concentration of cells around it increases and the induction of the follicular unit of adjacent epidermal cells is inhibited.

The study of the evolution of follicular units led to the HST technique

During the development phase of the cells, the latter differentiate into all components of the follicular unit, including the inner root sheet, the outer root sheet and the hair shaft. Studies by leading scientists have revealed that developing regions of follicular unity give rise to hair shaft.

They are closely linked. If either pathway is blocked during the cytodifferentiation phase, the follicular units convert into cysts. Hair follicle development involves a complex interaction of reciprocal epithelial mesenchymal signals. Most cells are controlled by a mutual interaction. Laminae and collagens are the two main fibrous protein systems of the skin that are at the origin of the development of the follicular unit.

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